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60 Resveratrol Health Benefits

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Resveratrol

Resveratrol and Estrogen

Resveratrol, an anti-oxidant compound found in red wines and grape skins, have found their way in diet food supplements that promise various health benefits. Its chemical structure is very mush similar with synthetic estrogen agonists - diethylstilbestrol, clearly suggesting that Resveratrol can act as an estrogen agonist.

Estrogens are known to be steroid hormones naturally produced in humans and other mammals with greater abundance in the female species. They are known to bind to estrogen receptors in cells that interacts with DNA to modulate estrogen-responsive genes.

Resveratrol-Estrogen Clinical Studies

Women with a known history of estrogen-sensitive cancers such as ovarian, uterine and breast cancers are advised to avoid supplements with Resveratrol contents until more tests are conducted to determine the estrogenic activity of Resveratrol in humans.

In recent clinical studies of cultured breast cancer cells, the action of Resveratrol appears to have both agonist and antagonist effect depending on cell types, estrogen receptor isoform as well the presence of endogenous estrogens.

On the other hand, other studies like those conducted by Dr. Eleanor G. Rogan, PhD, and her colleagues at the University of Nebraska, show that Resveratrol can reduce estrogen processing to toxic estrogen metabolites that react with DNA in breast cells to spread the growth of malignant tumor cells.

Working on cultured human breast cells, a Resveratrol concentration of 10 micromoles is enough to inhibit these metabolites from interacting with cell DNA. In other words, Resveratrol exhibits a promise of producing enzymes that destroy estrogen metabolites thereby inhibiting estrogen-bound cancers.

What it all means is that a glass of red wine containing 9 to 28 micromoles per liter of Resveratrol can have anti-carcinogenic effects in estrogen-caused cancer. But with conflicting clinical results, it is still best to wait for a more definitive finding especially on human patients. Until then, pregnant and lactating patients with these types of cancers should follow the above injunction against supplements with the substance.

By Admin, Resveratrols.org

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